Source: http://moviesblog.mtv.com/2012/01/09/dark-shadows-spider-man-brawl/
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By Todd Bishop
Geekwire
Posting from Las Vegas: OK, so this isn?t something you?re going to see in your living room anytime soon, but the Intel booth here features a pretty dramatic demonstration of the power of everyday computer processors.
Before the Consumer Electronics Show opens this morning, we got a sneak peek of the Intel booth, which is chock full of the thin and light Ultrabook notebooks that the chip maker is betting on to blunt the progress of the iPad in the portable computer market.
Overarching it all, literally, is a massive ?artificial ecosystem? that CES attendees will be able to interact with from kiosks on the edge of the booth. Check it out in our video above, along with an explanation of the technology behind it.
More from Geekwire:
?Todd Bishop is co-founder of GeekWire, a technology news site based in Seattle.
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By John W. Schoen, Senior Producer
The government offered fresh data Tuesday showing that the job market is gradually improving. But there still aren?t enough jobs to go around.
Even as hiring picked up in November, the number of jobs openings declined, according the Labor Departments? monthly Job Openings and Labor Turnover Survey (JOLTS).
Employers filled nearly 4.15 million jobs in November, up from a low of?3.6 million in October 2009 ? the lowest level in the 10 years the government has tracked the figure. That pickup mirrors the improvement shown in the Labor Department?s monthly employment surveys of households and employers. But it still badly lags the pace in the three years?before the recession hit, when employers were signing up more than 5 million new hires each month.
Though hiring picked up in November, job openings shrank by 63,000, to 3.2 million. October?s job openings were revised down by 43,000. ?
With 13.3 million people unemployed in November, there were about 4.2 job seekers for every?job opening, down a notch from the revised October ratio of 4.3-to-1. That is?roughly triple the ratio?seen before the recession hit in December 2007 but down from a peak of 6.9-to-1 in the summer of 2009.
?As the job-seekers ratio shows, what?s happening is not that millions of workers have become lazy, unskilled, or unproductive; it is that there are?not enough jobs available,? said?Heidi Shierholz, an economist at the Economic Policy Institute.
The drop in job openings was biggest for professional and business services (down 59,000) and government (down 18,000). Openings edged higher in construction (up 3,000), trade/transportation/utilities (4,000), education/health services (13,000), and leisure/hospitality (32,000).
The survey also showed an uptick in the number of people who quit their jobs, which is often seen as a sign of that workers are more confident about their job prospects with a new employer. But the number of quits in November was still well below the pre-recession peak.
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Researchers at the University of Iowa have worked out the exact function of an enzyme that is critical for normal muscle structure and is involved in several muscular dystrophies. The findings, which were published Jan. 6 in the journal Science, could be used to develop rapid, large-scale testing of potential muscular dystrophy therapies.
The enzyme, called LARGE, adds a critical sugar chain onto an important membrane protein called dystroglycan. This sugar chain acts like a glue allowing dystroglycan to attach to other proteins and by doing so, reinforce cell membranes in many tissues including muscle and brain. Dystroglycan does not function properly without this sugar link, and that malfunction causes muscular dystrophies and brain abnormalities.
"LARGE is a critical enzyme involved in maintaining muscle cell viability," says Kevin Campbell, Ph.D., professor and head of molecular physiology and biophysics at the UI Carver College of Medicine and a Howard Hughes Medical Institute investigator. "It adds on a unique sugar chain that allows the muscle cell to protect its membrane from injury. By figuring out the function of this enzyme we've finally identified this critical sugar link."
The new study shows that the enzyme activity of LARGE has two specific sugar-adding functions -- it transfers the sugars xylose and glucuronic acid. Using nuclear magnetic resonance analysis (NMR), the team was also able to determine the precise structure of the sugar chain produced by LARGE, which has not been seen before.
The study confirmed that this unique sugar chain is responsible for dystroglycan's ability to attach to its protein partners, which include laminin in muscle and neurexin in brain.
In addition to LARGE, several other enzymes are involved in building the important dystroglycan sugar chain, and mutations in all these enzymes cause congenital muscular dystrophies collectively known as secondary dystroglycanopathies. These disorders include Fukuyama Congenital Muscular Dystrophy, Walker-Warburg Syndrome, Muscle-Eye-Brain disease, Congenital Muscular Dystrophy 1C and 1D, and limb-girdle muscular dystrophy 2I.
However, in all cases, the part of the sugar chain that is critical for dystroglycan function is the part that is added by LARGE. Furthermore, work from Campbell's lab has shown that boosting LARGE activity in cells from patients with these types of muscular dystrophies is sufficient to restore dystroglycan function and overcome the defects in the cells.
By understanding what the LARGE enzyme does, the researchers have now been able to develop a test, or assay, to monitor enzyme activity.
"It's exciting that we now have this enzyme assay, which could be used in a large-scale high-throughput screen for drugs that increase (or decrease) LARGE activity," Campbell says.
Using the assay to identify compounds that boost LARGE activity might lead to potential treatments for the secondary dystroglycanopathies. The assay could also be used to look at variations in LARGE activity in patients' cells. This may help identify patients who are affected by these LARGE-related muscular dystrophies.
LARGE activity is important in other diseases
The unusual sugar chain that LARGE builds onto dystroglycan is also implicated in other diseases. A group of viruses that includes Lassa fever appear to require the sugar chain to infect cells. Lassa fever is a hemorrhagic illness that can cause serious disease and death.
Now that the researchers have determined the make-up of the unusual sugar, Campbell suggests that it will be possible to make and test it as a therapeutic to block or reduce infection by these viruses.
Campbell is also excited by another aspect of the Lassa fever link. A genome-wide study of populations in West Africa where Lassa fever is endemic suggests that the LARGE gene may be modified in this population. Campbell speculates that altering LARGE activity might provide some protection against infection by the Lassa fever virus. In the future, he hopes to use his team's newly developed enzyme assay to investigate if LARGE activity is altered in this population.
###
University of Iowa Health Care: http://www.uihealthcare.com/index.html
Thanks to University of Iowa Health Care for this article.
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LAGOS, Nigeria (AP) -- Nigerian lawmakers on Sunday turned against the president's decision to end government fuel subsidies that kept gasoline prices low, just ahead of a planned labor strike that could paralyze Africa's most populous nation.
Meeting in an emergency session, Nigeria's House of Representatives shouted down supporters of President Goodluck Jonathan as they voted for a resolution calling on him to restore subsidies that cost the country about $8 billion a year. But their moves failed to mollify unions organizing the strike set to start Monday.
"There exists a 1 percent cabal. It is upon this plank and premise the executive seeks to remove the subsidy," said Rep. Femi Gbajabiamila, a member of the opposition party Action Congress of Nigeria. "This cabal and their associates represent perhaps the biggest economic and financial crime in the history of Nigeria."
Gas prices have risen from $1.70 per gallon (45 cents per liter) to at least $3.50 per gallon (94 cents per liter) since the subsidy ended Jan. 1 at Jonathan's order. That spurred a spike in prices for food and transportation across a nation of more than 160 million people, most of whom live on less than $2 a day.
In response, two major unions have said they will carry out a strike Monday, despite a court order restraining them from it. That sets up a situation similar to one faced by the OPEC member nation in 2003, when strikers over eight days attacked shops that remained open, took over air traffic control towers and cut into oil production in a country vital to U.S. energy supplies.
Already, activists have begun a loose-knit group of protests called "Occupy Nigeria," inspired by those near Wall Street in New York. Their anger extends beyond just the fuel subsidy to the government's weak response to ongoing violence in Nigeria by a radical Muslim sect that killed at least 510 people last year, according to an Associated Press count. Protesters also remain angered by decades of corruption that has seen billions of oil dollars stolen by politicians as electricity and clean drinking water remain scarce.
During Sunday's session, televised live from the capital Abuja across the country, even members of Jonathan's ruling People's Democratic Party spoke out against him. Others said the fuel subsidy removal was undertaken without their knowledge, signaling Jonathan's administration moved unilaterally on an issue now dividing the country.
Some lawmakers also said the fuel subsidy removal could lead to a revolution like those that swept across some Arab countries last year.
"We are sitting near a keg of gunpowder and we are playing with fire," said Rep. Pally Isumafe Obokhuaime Iriase of the Action Congress of Nigeria. "This will be the last straw that will break the camel's back if we do not act."
Traffic snarled around gas stations in the country as motorists and generator users tried to buy gasoline before the strike. Some stations ran dry and closed early, while people waiting to buy fuel argued with attendants about filling extra gas cans.
Gabriel Gbaa, 34, said he remained angry about Jonathan's decision to raise prices as he filled his sedan with a jerrycan of gasoline.
"A lot of people are stuck in the village (because) they had gone to visit their parents" for Christmas, Gbaa said. "You should not decide something and force a vote on us. There should be dialogue."
Isaac Gbenga, a 27-year-old who works as a driver, said he supported the end of the fuel subsidies because it might tamp down on the country's notorious government corruption.
As a threatened midnight labor deadline neared, tempers flared at Lagos' Murtala Muhammed International Airport. A crowd of about 20 travelers trying to board one of the last flights out punched and pushed their way past airport security. Immigration officers and others forced them out after a 10-minute screaming standoff. Others resigned to not getting out simply slept on the airport's hard tile floor.
The government's effort to calm popular anger before the strike has failed so far.
The state-run Nigerian Television Authority cut away from shouting lawmakers at one point Sunday to show Jonathan attending an unannounced launching ceremony for a proposed mass transit program for the country. Speaking to a largely empty parade ground, Jonathan said some politicians could not attend as they were preparing for the coming Monday strike by "some societies."
The president also appeared personally stung by rampant criticism of him and his government on social media, making a point to mention how some erroneously said he had left the country to attend the 100th anniversary of the African National Congress in South Africa on Sunday.
"There are a lot of mischief makers that are going around misinforming Nigerians, especially using the social networks, the Twitter, (BlackBerry messenger), the Facebook and others," Jonathan said. "But that is Nigeria for you: there's a lot of wrong information that is being put into the system to confuse Nigerians."
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Jon Gambrell can be reached at http://www.twitter.com/jongambrellAP .
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In this photo provided by Jordanian News Agency PETRA, Palestinian President Mahmoud Abbas, left, holds hands with King Abdullah II of Jordan as they meet in Amman, Jordan, Tuesday, Jan. 10, 2012. President Abbas says talks between chief Palestinian and Israeli negotiators have provided an 'important opportunity' for reviving direct negotiations. "We must take this chance," Abbas told reporters after talks with Jordan's King Abdullah II in Amman on Tuesday. (AP Photo/PETRA)
In this photo provided by Jordanian News Agency PETRA, Palestinian President Mahmoud Abbas, left, holds hands with King Abdullah II of Jordan as they meet in Amman, Jordan, Tuesday, Jan. 10, 2012. President Abbas says talks between chief Palestinian and Israeli negotiators have provided an 'important opportunity' for reviving direct negotiations. "We must take this chance," Abbas told reporters after talks with Jordan's King Abdullah II in Amman on Tuesday. (AP Photo/PETRA)
In this photo provided by Jordanian News Agency PETRA, Palestinian President Mahmoud Abbas, left, listens to King Abdullah II of Jordan during a meeting in Amman, Jordan, Tuesday, Jan. 10, 2012. President Abbas says talks between chief Palestinian and Israeli negotiators have provided an 'important opportunity' for reviving direct negotiations. "We must take this chance," Abbas told reporters after talks with Jordan's King Abdullah II in Amman on Tuesday. (AP Photo/PETRA)
JERUSALEM (AP) ? Israel stepped up settlement building in the West Bank in the first nine months of last year, an Israeli watchdog group said Tuesday, underlining the issue that has deadlocked peace talks with the Palestinians.
The anti-settlement group Peace Now said Israel began construction of about 1,850 homes in West Bank settlements in the first nine months of 2011, about 20 percent more than all of the previous year.
The 2010 figures were depressed by a 10-month freeze on new construction that Israel imposed in hopes of encouraging negotiations. Talks barely got off the ground. Once the freeze expired in September 2010, Israel resumed construction, and the Palestinians stopped the talks.
The issue of settlement construction persists as the heart of the current impasse in peace efforts.
The Palestinians say they will not resume negotiations as long as Israel continues to build in its settlements in the West Bank as well as in east Jerusalem, areas captured by Israel in the 1967 Mideast war and claimed by the Palestinians for their future state.
Israel insists on negotiations without conditions, noting that the Palestinians have not demanded a settlement construction freeze as a condition for talks in the past.
The Palestinians say continued construction in these areas, now home to roughly 500,000 Israeli settlers, is a sign of bad faith. Israel annexed east Jerusalem after the 1967 Mideast war and does not consider housing there to be settlements. The international community does not recognize the annexation.
The Israeli government keeps its own statistics on construction. During the same nine-month period, Israel's Central Bureau of Statistics reported less than half the construction starts that Peace Now reported.
Peace Now spokeswoman Hagit Ofran said the government's figures are lower because of different methodologies. She said the government depends on numbers reported by local settlement authorities, while Peace Now conducts on-the-ground and aerial monitoring that also looks at illegal settlement construction in locations the Israeli government has not approved.
Israeli government spokesman Mark Regev rejected the criticism, saying that Israel continues to "exercise great restraint" in its settlement construction.
He said Prime Minister Benjamin Netanyahu has come under heavy criticism by settler leaders for not building enough in the West Bank.
"We have shown more restraint on the issue of settlement than any previous Israeli government," Regev said.
Last week, Israeli and Palestinian negotiators began low-level talks in neighboring Jordan in hopes of finding a formula to restart formal negotiations.
In Amman, Jordan, Palestinian President Mahmoud Abbas said Tuesday that these preliminary talks provide an "important opportunity" for restarting the peace process.
Abbas said hopes for success are "weak." Even so, "we must take this chance," Abbas told reporters after meeting Jordan's King Abdullah II.
Abdullah, who is hosting the talks, is scheduled to meet President Barack Obama at the White House on Jan. 14. Abdullah said that meeting would focus on restarting serious Mideast negotiations.
___
Associated Press writer Dale Gavlak in Amman, Jordan, contributed to this report.
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January 8, 2012
The Third Annual Charlottesville Wedding Classic was held at the Boar's Head Inn on Sunday. The event served as a one-stop shop for all wedding planning needs.
Bride-to-be Holly Turner attended the event hoping to get ideas for her special day.
"It is a little bit overwhelming, but it's also really nice to have everything in one place," said Turner.
More than 40 vendors, offering services that ranged from photography to cakes, participated in the expo this year.
"We have a vendor list. We have a preferred vendor list. We can make suggestions for them. I think, I don't know if it would be a mom, but it certainly would be a big sister," said Pat Burnette, marketing and communications manager at the Boar's Head Inn.
Eager couples also had the opportunity to attend a fashion show featuring bridal gowns and menswear.
?So far, I have only really picked a date and looked for a ceremony and reception venue. I haven't gotten to the dress yet,? said Turner.
Turner's wedding date is more than a year away, which gives her plenty of time to find the perfect fit.
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